The outlook depends on where the gangrene is in the body, how much gangrene there is, and the person's overall condition. If treatment is delayed, the gangrene is extensive, or the person has other significant medical problems, they may die.

Complications depend on where in the body the gangrene is, how much gangrene there is, the cause of the gangrene, and the person's overall condition. Complications can include:

• Disability from amputation or removal of dead tissue
• Prolonged wound healing or the need for reconstructive surgery, such as skin grafting

Call your doctor immediately if:

• A wound does not heal or there are frequent sores in an area
• An area of your skin turns blue or black
• There is foul-smelling discharge from any wound on your body
• You have persistent, unexplained pain in an area
• You have persistent, unexplained fever

Gangrene may be prevented if it is treated before the tissue damage is irreversible. Wounds should be treated properly and watched carefully for signs of infection (such as spreading redness, swelling, or drainage) or failure to heal.

People with diabetes or blood vessel disease should routinely examine their feet for any signs of injury, infection, or change in skin color and seek care as needed.