Gangrene is the death of tissue in part of the body.

Gangrene happens when a body part loses its blood supply. This may happen from injury, an infection, or other causes. You have a higher risk for gangrene if you have:

• A serious injury
• Blood vessel disease (such as arteriosclerosis, also called hardening of the arteries, in your arms or legs)
• Diabetes
• Suppressed immune system (for example, from HIV or chemotherapy)
• Surgery

The symptoms depend on the location and cause of the gangrene. If the skin is involved, or the gangrene is close to the skin, the symptoms may include:

• Discoloration (blue or black if skin is affected; red or bronze if the affected area is beneath the skin)
• Foul-smelling discharge
• Loss of feeling in the area (which may happen after severe pain in the area)

If the affected area is inside the body (such as gangrene of the gallbladder or gas gangrene), the symptoms may include:

• Confusion
• Fever
• Gas in tissues beneath the skin
• General ill feeling
• Low blood pressure
• Persistent or severe pain

The doctor may diagnose gangrene from a physical examination. In addition, the following tests and procedures may be used to diagnose gangrene:

• Arteriogram (special x-ray to see any blockages in the blood vessels) to help plan treatment for blood vessel disease
• Blood tests (white blood cell (WBC) count may be high)
• CT scan to examine internal organs
• Culture of the tissue or fluid from wounds to identify bacterial infection
• Examining tissue under the microscope to look for cell death
• Surgery to find and remove dead tissue
• X-rays

Gangrene requires urgent evaluation and treatment. In general, dead tissue should be removed to allow healing of the surrounding living tissue and prevent further infection. Depending on the area that has the gangrene, the person's overall condition, and the cause of the gangrene, treatment may include:

• Amputating the body part that has gangrene
• An emergency operation to find and remove dead tissue
• An operation to improve blood supply to the area
• Antibiotics
• Repeated operations to remove dead tissue (debridement)
• Treatment in the intensive care unit (for severely ill patients)